eLife4h
eLife appoints Timothy Behrens as Editor-in-Chief
As Editor-in-Chief, Behrens is responsible for the editorial direction and vision of the journal, providing leadership to ...
eLife2h
Early and delayed STAT1-dependent responses drive local trained immunity of macrophages in the spleen
In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.
eLife19h
Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization
Integral membrane proteins carry out essential functions in the cell, and their activities are often modulated by specific protein-lipid interactions in the membrane. Here, we elucidate the intricate ...
eLife19h
Chromatin activity of IκBα mediates the exit from naïve pluripotency
This important study reveals a role for IκBα in the regulation of embryonic stem cell pluripotency. The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to ...